Honestly don’t know the real difference. I just know i want something that holds enough if i ever have to use it here in philly. I also might want to modify it later onCheck out S&W M&P 2.0, Sig 320 and some 1911's (Springfield). They are good for people with small hands, the grips are small.
It's best to go to the range and try different guns, glocks tend to have larger grips.
Are you looking for a fullsize or compact handgun?