A Boss could give up bosses of other families...they could roll on the people under them on some unsolved murders and shyt, drugs, etc.... Could (literally) tell them people where the bodies are buried, could have wore a wire, etc...
Gravano was pretty much the street boss of the Gambinos, he ran things on the day to day while Gotti basked in his glory...and he snitched after they had him for like 20 bodies and all types of wild shyt, they had him dead to rights and wanted him but still let him give up info and get a deal.... not just on Gotti but other bosses/underbosses in other families, etc...
The Feds aint turning down intel, good and substantiated intel that you better not be lying about or they're really gonna fukk you over. A boss has so much information they probably get wet just off the idea of them cooperating, it's rare tho...it's actually more likely with the black gangs/organizations than the Italians and Russians and them. If Meech rolled over he could have blew the whole drug game up on a certain level...but he decided to stay solid and do his time.
Supreme could have cooperated, all day, but he would never, too much pride. Too solid.