Holland could literally do this for the next 20 yrs lmfao, and this film kinda solidifies him as "Spiderman 1" pun intended.
He could, sure - but let's be conservative and say the next trilogy takes about 7 years starting from now (with big event MCU cameos sprinkled in), he'll be 32 at that point with a ton of miles on his tires.Honestly I could see Holland doing two more trilogies if he actually wants to. They casted him young for a reason.
There was talk of a middle trilogy with him in college and then a final trilogy with a more adult late 20s/30s Spidey.
Now I'm not saying he wants to, I don't know, but Holland is only 25 (and looks younger) so dude can play Spidey for another 15-20 years if he really wants to.
He's already spoken about not wanting to commit to the role beyond 30 because of the amount of time you devote and the toll it takes on your body. Some of that was for leverage in his new contract negotiations, but I don't think it was all fabricated. He'll show up for a major Spider-Verse scenario but I'd be shocked if he's doing a full blown 3rd trilogy between 32 and 40.