The original Mass Effect trilogy is done and over with and if Bioware is smart they'll never touch anything related to that story again.i'm hoping that they use this trilogy to somehow circle back around to those things....they need to just go with the fan theory that me3 is pretty much the reapers trying to indoctrinate shepard the whole game, and go from there....meA can take place while all that shyt is taking place...in meA2 we should come back to our system and fight the reaper shepard while trying to free the real shepard...meA3 we should finally get to fight harbinger....seriously, if we go 6 games without fighting him, i'm done with ME, i dont give a fukk how much i've enjoyed the series.....
That stuff was a mistake they can't take back so they did the next best thing and made a clean break with it. there's a reason they set up Andromeda like they did with almost no ties to that first trilogy.
That being said Mac Walters is still heavily involved in this new game and seeing as how he ruined the ending of Mass Effect 3 maybe we should lower expectations.