For SM3, I think at least one Osborne will remain heavily involved for the emotional heart beats but I get what
@Gizmo_Duck is saying. i.e. Green Goblin is by far the most important villain in Spider-Man lore... but notice Venom is who you tease in all the marketing because he's the most popular villain, to keep it a buck.
For the general public, the only thing bigger than Spidey, is Spidey and Miles, and the only thing bigger than Spidey and Miles... is Spidey, Miles,
and Venom. So I wouldn't be surprised if all 3 became playable in SM3, and we all know the villain that always forces Spidey and Venom to put aside their differences to take down. I could see a rendition of
that story line being incorporated.