Interesting, I enjoyed Luke Cage. I think the marvel formula failed it, shyt didn't need as many ep's as it did per season. But yeah joking aside, I could see Spike Lee helming an episode of Luke Cage, hell maybe even Captain America and The Winter Soldier, Spike Lee isn't a scrub at ALL. But naw, I can't see him being the director of an entire Marvel(Superhero) film. That's just not his type of shyt.
Oh he could do it for sure, but it has to be the right character and there will be some obvious constraints about the action scenes and maybe plot points to work around. But picture New Jack City with a Luke Cage type nikka running around...that's where the show was heading anyway, having him go deeper into the underworld.