Game is great. Few little criticisms though, the melee is pretty meh (no reason not to have a guard, especially when your human opponents do), the loot system appears to be nowhere near as satisfying as something like Ni-Oh or Borderlands or Diablo, and the UI doesn't give much information about weapons, effects etc. Also some of the dialogue is ass. The editing from game to cutscene is often weird.
Story, combat (as a whole), crafting, the world, soundtrack, the visuals, the characters etc are all first class though. They've taken all the best aspects from Uncharted, the Witcher, Far Cry and a couple of others and have polished and improved on them. The exception being loot but maybe that'll get better.
Also I think the facial animation is really fukking good, with the exception of the mouths, which sometimes look unnatural. Looks a million times better than what you get in Bioware games for example. ME:A looks trash in comparison.