That everybody can get it humor was part of the GTA appeal. It was a core component of their world building. Straight white men are goofy and stupid, yes, but I don't think there's enough comedy to be mined from that demographic now that everyone is forced to draw from that well. That pool of humor shytting on Trumptards, gamer bros, incels and even the generic male himself is going to be looking like Lake Mead soon.
Well, I guess we'll get some over the top liberal strawman to even things out but I mean that's just equal to an average episode of SNL. As much as people hate Seth McFarland he has done pretty well in balancing political correctness with edgy humor. Well, decent enough not to be canceled via Twitter anyway. It's a fine line though and Rockstar probably doesn't want to risk it. GTA 6 is rapidly becoming a life or death situation for them. They will either continue to be a ground breaking prestige studio or just the caretakers of GTA online. We shall see.
Honestly if they don't want that sort of humor in their games anymore that's fine but if that's the case retire the franchise and start a new IP in line with this new creative direction/world building.