Pretty sure you gotta beat Vicar, Shadows of Yarnam and Rom to be able to get to The One Reborn and MicolashThat's why I said "clean up everything including the dungeons"
http://www.thecoli.com/threads/bloodborne-ot-march-24-2015-ps4.224432/page-84#post-12875541
Now that I think about it, you only have to play three bosses (Father Gascoigne, The One Reborn and Micolash Host Of The Nightmare) to get to Mother Brain...correct me if I'm wrong.
Only took me like an hour and half to get to Rom anyway. Just running through unlocking shortcuts and sprinting to the bosses
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