Basically this
Stay the fukk out of woodland hills or anything past Sepulveda Blvd. in the valley, way too much traffic. TBH. Downtown LA isn't too bad. There's tons of clubs and bars out there.
Look for places in this descending order to avoid traffic: Silver Lake > Pasadena(old) > Glendale > Burbank > Toluca Lake > Studio City > North Hollywood....
Rush hour traffic is no joke. Not to mention depending on where you live there might be a heavy concentration of traffic on the weekends too, or you may have trouble finding parking for the simplest of things.
I actually like west valley. Used to work in woodland hills, my commute was Noho to Woodland Hills so I used to stay out there for happy hour until traffic died then I'd head back home, eat dinner, then head over to hollywood. I became familiar with encino and woodland hills and it wasnt that bad. Lotta nice persian chicks and hookah bars.
Im telling you, Studio City and Noho is the perfect place. Its only 4 exits away from hollywood bvld, night life, and you can take ventura to beverly glen to get to west la/west hollywood. its a real nice central area, and its right next to burbank, another coo spot to chill. when I needed to go to Downtown lounges, underground art galleries, The standard, downtown restaurants, I just took the redline. the first stop is IN Noho. I also had easy access to studio city (one exit) I took chicks over to city walk to watch IMAX and drink over at saddle ranch and dance at the rumba room. Lotta people sleep on North Hollywood. its an art district and newly gentrified. If you get plastered on Hollywood Blvd, its only a $10 taxi ride back home. The hollywood bowl is like 4 exists away, the Rose Bowl (UCLA games) is right off the 5 which you can catch. basically you can catch all freeways from north hollywood, from 5 to 134 to 170 to 101 to 405 (if you drive west to sepulveda). You can take the redline to get to the staple center also.
I head back home in 3 weeks, Imma be staying a cpl weeks with my homegirl in chatsworth, now THAT is fukking wack. stay away from North Valley
....stay south of Magnolia and north of santa monica (hollywood).