I really really really want to put the Sopranos as #1, but they had some undeniably weak and baffling episodes that threw off storylines...The Wire was a seamless, serialized narrative that improved on everything the Sopranos did and then some...
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It doesn't have the family dynamic that The Sopranos had. There are some familial threads woven into the story, but nothing compared to what The Sopranos did.
The one thing that The Wire doesn't have, which may set it back in some people's minds, is a dominant singular character/performance. It doesn't have a Walter White, Don Draper, Tony Soprano, etc.