Cable is from the 616 reality. His mother is Madelyne Pryor..the clone of Jean Grey created by Sinister during Claremont's golden run before Inferno. He was given the TO virus by Apocalypse in X-Factor, went to the future with Askani, got cloned to help keep him alive and has to use his TK to keep that shyt in check. He was made the "Chosen One" and all of that garbage in the 90s and was positioned as a Apocalypse arch enemy
Nate Grey is from the AOA..was made by Sinister with Cyclops and Jean Grey's genetic material. He never had the TO virus, doesn't give a fukk about Askani or destinies, and basically had the power to stop Apocalypse from the get go but didn't have the training. Genetically he and Cable are the same but two different type of characters as Nate is very impulsive and in his original run would lash out recklessly at anyone who came at him.