I think the hard hits will start from #4 onward. Especially considering its the end of the "Nation" arc. Would be a big missed opportunity if something big doesn't happen then. There's more than enough build-up at this point.
Isn't Manifold appearing soon? I suspect a little globe hopping will be in order. I honestly wouldn't be too surprised if T'Challa starts kicking ass and taking names once Shuri reappears to the living