Nope.
The world and story of 1 was the best. In the rest of the series there is nothing comparable to the first time you land on the Citadel, or hear Sovereign, or find all the dead Protheans, etc. Because the entire universe and characters are new in the first game.
As an actual game....as far as game play, how it controls, etc. the 2nd game is the best in the series over all. It's not even about the RPG elements.....because they were mostly a mess in part 1. Some of the skills unintentionally cancelled each other out or didn't function properly. Not to mention you're a soldier but if you don't put skill points in guns you can't even shoot straight. Some of the design choices were very bizarre.
But RPG heads just seen all the options like
Granted, they removed way too much of that in 2 and 3, when they should've just refined it.
Fred.
2 is easily the best