Well, AOC is only 35 years old and likely has a long future in Congress. I would bet at some point she runs for President.
I don't think 2028 is a realistic time frame.
It was a hard pill to swallow for a lot of people, but the Democratic Party really cut one of their legs out by embracing an establishment candidate like Hilary Clinton in 2016 and again with Biden in 2020 when a significant part of the country was open to a more "populist" candidate like Bernie Sanders.
My guess is that 2028 is the Gavin Newsom candidacy, although Pete Buttigieg could make yet another push. Amy Klobuchar seems nice but I don't think anyone cares about her one way or the other on a national level.
AOC would likely get way too much pushback from the establishment and mainstream Democrats. Plus there might be this fear that running a 3rd woman at this time is politically risky.