These Prizm cases that are $10K+ now were around $1,000 2-3 years ago. We're in completely uncharted territory with these prices. This used to be reserved for classic, older sets (think '86 Fleer Basketball per box or '96 Topps Chrome Basketball).
If you buy one of these cases, are you planning on opening everything? If so, grading is the only way you'll maximize your return. Unfortunately, the wait times are insanely long right now and if you use the quicker services, they cost an arm and a leg. It starts at $100/card for non-members for the lowest level, which could take 9+ months to get back. I'm not sure what the best rate you can find with bulk submitters is; maybe $50-75? It used to cost $10-20 to get most card graded before.
Damn, that big of a difference with those cases?
I would plan on getting some graded. What would the reason be to not open all of them? Just keep them sealed and hope it goes up in value and someone buys down the road?