Facts
Spence would get hit moreso because his offense failed or he ain't move his head in certain spots. Besides the Porter war and Bud dismantling, you're not gonna see Spence get hit flush multiple times throughout a fight. Sure he'll get clocked some on occasion, but nowhere as much as Tsyzu does.
Tim gets lit up trying to get to you. He gets hit on offense and defense and inbetween punches. His style presents more opportunities to catch him than Spence does. Hell, even that one nikka who barely throws punches (I forget his name, but he got a draw against Trout) managed to drop Tim the one time he decided to punch.
Well said. Spence neck and chin are usually really tight and tucked in, same goes for his right hand, its his left hand that can give him issues defensively, but I'd argue this is more due to him using it a lot, or as you said, sometimes having his head in an exposed position, during or post punch. eg Crawford was able to time him every time he came in, because of his left hand leaving his face and it being exposed.
@Knicksman20 you made a good point about Spence footwork, and it's true, it's predictable, he has never been a bopper style fighter or a slip style southpaw eg Pernell Whitaker. Spence relies on his high guard, sitting low, head shift off the line slightly, and his right foot to step/pivot, but that's the bulk of his movement. I'd argue his method is extremely simple, he backs in his tight guard, his punch output and his ability to outwork the opponent. It's a battle of determination and fitness with Spence, he's pretty simple aside from that. He's there to outwork you.
The issue now, as you said, is his punch resistance, and whether or not he can keep up this 'fitness battle' at the rate required. His fitness dicates everything, even his high guard. Your max v02 diminishes every year after 20, pretty hard to win a fight of fitness when you get less fit biologically as the years go by.