Tips and tricks:
Cap the frame rate/potentially improve frame times (1): Download
RivaTuner Statistics Server, input your desired framerate limit in the "Framerate limit" box, and hit enter (the program comes bundled with
MSI Afterburner and earlier versions of EVGA PrecisionX). Alternatively, those with an Nvidia GPU have the option of
Nvidia Inspector, which can also be used to impose a framerate cap, either
in a similar manner to RTSS or by way of forcing a different vsync interval (click the small tool icon to open the game profile section).
Note: Useful if you your system can't maintain, say, 60fps and you're sensitive to the wild fluctuations, or you're experiencing uneven frametimes. The greater window the engine has to render a given frame, if you're imposing a lower framerate than the game can otherwise provide, may also help in alleviating stuttering related to data streaming.
Potentially improve frame times (2): Use exclusive fullscreen rather than borderless fullscreen.
Stop the game from crashing after 15 minutes on touch-capable systems running Windows 10: Open the task manager, switch to the Services tab and disable TabletInputService.
Fix washed out colours: Tweak your display settings. See
this post for recommendations. (Credit to
Paragon.)
Disable sharpening and/or cutscene letterboxing: Apply
these patches to the game's executable. (Credit to jackfuste @ WSGF via
disgraciau.)
Fix freeze upon interacting with the laptop in the main hall: Open SteamApps\common\RESIDENT EVIL 2 BIOHAZARD RE2\re2_config.ini and set
UseVendorExtention to disable. (Credit to
Valkerion.)
Disabling vignetting: Use
this tool. (Credit to susahamat @ WSGF via
The-Depth-In-Us.)