When do yall suggest I crank it up to mayhem 10? I restarted in tvhm mode at mayhem 10 but after rampager the difficulty spike forced me to turn it down to 3. Am I missing any good legendaries playing through the rest of the story at mayhem 3?
There's some loot that doesn't drop at levels lower than Mayhem 6, so you want to work your way up to there at least.
Did you go straight to Mayhem 10? The way they designed it, well rolled gear from about two Mayhem levels lower is viable for in higher levels, and anything below that starts getting tough. I'd say if you don't care about sinking some time, farm for a couple of decent legendaries with ok rolls at 3, then crank it up to 5 or 6, farm again, go to 8, farm again, and then just roll through 10.
I hvent played in a bit, but as I remember it, the biggest difference between 8/9 and 10 is the extra debuff. If can get comfortable in the middle levels, the later levels are manageable with the right build and gear.