I got the tip that about an hour in there are a couple scenes you can bounce on if you gotta piss. One of them is people eating lunch together and the other is two people who seem to be romantically involved having a conversation. I was told you'll know the moments when you see them.
Honestly the first hour or so you can go to the bathroom at any time. Missing 5 or so minutes ain't gonna change anything.
The second hour and especially the 3rd, not so much.
Fred.