Official H5N1 (Bird Flu) Thread

[Gloxina]

@bnew @Gloxina @wire28 @Killer Instinct

Erin Candy 🍒🇨🇦 (@erincandy.bsky.social)

RED ALARM on H5N1. Data dump late last night from the BC teen shows that the sequence has picked up the necessary mutation needed for adequate transmission among human hosts. It’s got PB2 E627K. The same mutation that 1918 Spanish influenza had. We’re going to have a pandemic. Buckle up.

bsky.app

Freaking knew it.



Stock up, folks and get ready. My house will be stocked so when they announce this shyt I’ll be chilling.


This is going to be the second pandemic under Trump.
Smdh

 

[Gloxina]

https://www.koin.com/news/oregon/oregons-first-human-case-of-avian-influenza-reported-by-health-officials/

Uuuugh

 

[bnew]

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1/3
@HNimanFC
Full /search?q=#H5N1 D1.1 seq released for BC Teen

A/British_Columbia/PHL-2032/2024

N1 S247 (wild type)
Looks pretty typical so far
Not in BLAST database yet



2/3
@HNimanFC
OOPs
Spoke too soon
Mixed signal for PB2 E627K



3/3
@HNimanFC
All 8 seqments of BC teen
A/British_Columbia/PHL-2032/2024
closely related to recently uploaded
/search?q=#H5N1 genotype D1.1
BC wild birds
BC poultry




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1/12
@HNimanFC
RED FLAG Warning
H5 seq of BC Teen
mixed signals at TWO key positions
E202X is position 190 using H3 numbering
G238X is position 226 using H3 numbering
226 and 228 are THE key positions in HA RBD
also has mixed signal for PB2 E627K
Three key changes in GoF studies (226 228 627)



2/12
@mrmickme2
We’re screwed



3/12
@HNimanFC
"Amino acid substitutions E190D, Q226L, or G228S (H3 numbering) in the HA gene that are known to enhance binding to mammalian receptors"

E202X is mixed signal for E190D using H3 numbering

Genetic Characterization of Highly Pathogenic Avian Influenza A(H5N6) Virus, Guangdong, China - PMC



4/12
@DrTrenton
layman's terms?



5/12
@HNimanFC
H5N1 is an avian sequence
To transmit efficiently
change key positions
Gain of Function studies
key changes required for mammalian (ferret) transmission
three key positions
HA at positions 226 and 228 (using H3 numbering)
PB2 at position 627
HA at 190 implicated in other studies



6/12
@AshleyFortune13
Well, maga going to get their chance to ignore science and win Darwin awards again. It’s coming.



7/12
@beahaven
Just in time for the holidays.



8/12
@chrismandz
Do we know how the term is doing?



9/12
@a_better_world2
Thank you for your information. Deeply appreciated.



10/12
@Coffee4Life365
Oh crap
@R_H_Ebright @WashburneAlex @MeetJess @beansprouts_mom @NaphiSoc



11/12
@Heyheydownthes1
Can i please have some coffee before reading this?



12/12
@danwalker9999


[Quoted tweet]
H5N1
We are currently at stage 3 in the virus's progression, transitioning from the avian phase to the mammalian phase, and now entering the stage of potential human spillover.

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1/4
@HNimanFC
Here is the bottom portion of the updated GISAID H5 tree which has added the BC teen and one of the BC farm /search?q=#H5N1 D1.1 seqs
Branch of interest is at the bottom

2/4
@HNimanFC
Here is the bottom portion of the updated GISAID N1 tree which has added the BC teen and one of the BC farm /search?q=#H5N1 D1.1 seqs
Branch of interest is at the bottom
has labeled the 3 seqs with S247N (Tamiflu resistance)
From 3 cullers infected in Franklin Co WA
who traveled to OR

3/4
@HNimanFC
Names of the seqs
protocol for flu seqs (also adopted for SARS)
Fields seperated by /
A/British_Columbia/PHL-2032/2024
A = Influenza A
no species = human seqs don't include species
British_Columbia = location
PHL-2032 = sample number from Public Health Lab
2024 = collection year



4/4
@HNimanFC
GISAID tacks on precise collection date of sample
for BC teen
A/British_Columbia/PHL-2032/2024
only give year and month of collection (2024-11)




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[bnew]

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1/2
@HNimanFC
"(HPAI) was detected in a backyard flock of various birds in Central O‘ahu"
/search?q=#H5N1 confirmed in Hawaii
AVIAN INFLUENZA CONFIRMED IN BACKYARD FLOCK OF BIRDS.



2/2
@HNimanFC
"matches the strain that has infected dairy cows and domestic poultry on the U.S. mainland"
/search?q=#H5N1 genotype B3.13 in Hawaii Backyard Farm




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1/1
@HNimanFC
/search?q=#H5N1 definitely on the move
"Poultry at a commercial farm in Pinal County recently tested positive for bird flu"
Arizona
My guess of genotype D1.1 based on Pacific Flyway
Poultry at Pinal Country commercial farm tested positive for avian influenza




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[88m3]

free eggs

 

[bnew]

Freaking knew it.



Stock up, folks and get ready. My house will be stocked so when they announce this shyt I’ll be chilling.


This is going to be the second pandemic under Trump.
Smdh

every country or state that didn't vote for him won't be getting any federal aid or a very little help at all because as he's said before, "those aren't my people".

 

[bnew]

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1/8
@erincandy
I hope people realize we are about to have an H5N1 pandemic. The sequence in BC they dumped the data late last night and it shows it’s picked up the necessary mutation needed to be an efficient human host. It’s highly pathogenic, it’s deadly, and it’s now got what it needs to spread among humans. It’s got the same mutation as 1918 Spanish influenza. Brace yourselves.



2/8
@erincandy
You can pretend all you want like Covid but the 58% mortality rate won’t care.



3/8
@erincandy
The sequence found was the dreaded PB2 E627K. This is what we have been warning about happening

4/8
@erincandy
The Effect of the PB2 Mutation 627K on Highly Pathogenic H5N1 Avian Influenza Virus Is Dependent on the Virus Lineage

(Spoiler: ITS NOT GOOD)

The Effect of the PB2 Mutation 627K on Highly Pathogenic H5N1 Avian Influenza Virus Is Dependent on the Virus Lineage - PMC



5/8
@erincandy
This mutation is the one needed to spread efficiently among 37 C degree human hosts. Game over.



6/8
@erincandy
Oh great it also has antiviral resistance mutation with N329.

We are so fukked.

This is

7/8
@erincandy
This is in Canada, btw.



8/8
@erincandy
You are here

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[bnew]

Mark Chadbourn (@chadbourn.bsky.social)

For those asking, the CDC hasn’t released full details about the case beyond the fact that the infected person was linked to a poultry operation where there had been a previous outbreak,

bsky.app

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1/2
@Mark Chadbourn
Oregon has reported its first human case of H5N1 bird flu. Now 55 cases nationwide.

2/2
@Mark Chadbourn
For those asking, the CDC hasn’t released full details about the case beyond the fact that the infected person was linked to a poultry operation where there had been a previous outbreak,


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[Gloxina]

Spoiler: thread continued

Spoiler: full text & large images

1/8
@erincandy
I hope people realize we are about to have an H5N1 pandemic. The sequence in BC they dumped the data late last night and it shows it’s picked up the necessary mutation needed to be an efficient human host. It’s highly pathogenic, it’s deadly, and it’s now got what it needs to spread among humans. It’s got the same mutation as 1918 Spanish influenza. Brace yourselves.



2/8
@erincandy
You can pretend all you want like Covid but the 58% mortality rate won’t care.



3/8
@erincandy
The sequence found was the dreaded PB2 E627K. This is what we have been warning about happening

4/8
@erincandy
The Effect of the PB2 Mutation 627K on Highly Pathogenic H5N1 Avian Influenza Virus Is Dependent on the Virus Lineage

(Spoiler: ITS NOT GOOD)

The Effect of the PB2 Mutation 627K on Highly Pathogenic H5N1 Avian Influenza Virus Is Dependent on the Virus Lineage - PMC



5/8
@erincandy
This mutation is the one needed to spread efficiently among 37 C degree human hosts. Game over.



6/8
@erincandy
Oh great it also has antiviral resistance mutation with N329.

We are so fukked.

This is

7/8
@erincandy
This is in Canada, btw.



8/8
@erincandy
You are here

To post tweets in this format, more info here: https://www.thecoli.com/threads/tips-and-tricks-for-posting-the-coli-megathread.984734/post-52211196

We are fukked

 

[jj23]

Spanish flu killed at least 50 million.

Bird flu killing in the 100's of millions means a total global reset.

AI assistance in every task would be inevitable.

Man this really feels like a simulation.

 

[Gloxina]

Spanish flu killed at least 50 million.

Bird flu killing in the 100's of millions means a total global reset.

AI assistance in every task would be inevitable.

Man this really feels like a simulation.

Yea. This might be the big one.

What is Disease X | Johns Hopkins Bloomberg School of Public Health

Public health agencies and governments across the globe are always readying their response for the next infectious disease emergency, but how do we prepare for the truly unknown? Enter Disease X.

publichealth.jhu.edu

 

[jj23]

Also one good thing is that there is a vaccine for H5N1, so tweaking it for a new strain and getting it out should be easier than it was with covid.

If in the further your yearly flu vaccine covers H5N1 brehs.....crazy shyt...

 

[Gloxina]

Spanish flu killed at least 50 million.

Bird flu killing in the 100's of millions means a total global reset.

AI assistance in every task would be inevitable.

Man this really feels like a simulation.

I guess it’s time to get into an AI bootcamp so we’ll have jobs after the reset 🫠


But for real they’ve been talking about population reduction for a minute. They won’t stamp this shyt out quickly.

 

[newarkhiphop]

Reading through some Bluesky stuff. I don't think we will have a Pandemic at the moment, because it seems that everyone who has been getting sick... has been getting it from contact with other Animals, mostly Cows. Until there is spread from Human to Human, then it be more worrisome, which can still happen but right now everyone that's been getting sick has been getting it from animals.

Unfortunately we are a couple of months away from there. COVID taught us nothing

I have a friend who works with the cdc and even the Biden administration was handcuffing them, with Trump and them in office believe it or not we are right back at 2020

I've already began stocking up on mask, flu medication etc

Winter is coming

 

[Serious]

2024 going out with a bang

CNN (@cnn.com)

The United States' first known case of a more severe strain of mpox was confirmed in California, the CDC says. https://www.cnn.com/2024/11/16/health/mpox-clade1-california-first

bsky.app