I expect the MCU to completely kill of and and change the rest of the marvel 616 once they get rolling.
The xmen will be antsy, LGBTQ spokes persons.
The FF will be some weird CW like family
And cosmic threats and street level villains will be like saturday morning cartoon villains.
It's a gift and a curse, I think the marvel comics and games has taken nothing but a nose dive since the success of the movies.
And that's probably ok for marvel because all in all it's about exposing the brand and selling product, and the MCU does that and will continue to do that if they make these movies and disney + shows right.