Kanye or Em. The two most popular artists from the Midwest. Kanye has a bigger cultural impact, and in terms of anthems Homecoming anyone? Eminem sells the most, but that's simply because White kids love him. So Kanye. I would love to say the Bone Thugs, because I'm from Cleveland, but if you say E 99th and St Clair, no one will know what you're talking about. You say 8 Mile and White kids will suddenly remember that they like saying "nikka" when they're with their White friends. Twista? No. He has staying power, but there isn't a chance of him being the king of Midwest with the others there.