All depends on where you live and where you're traveling.
Got fam in the PNW. They live close to an airport but it's a small, regional joint. We ALWAYS gotta connect somewhere, either SLC, DEN, SEA etc. East Coast fam, we're either landing at Orlando Intl or LaGuardia.
In Texas, we just drive...but driving in Texas can take all day, especially if you're going across the state or all the way down to the Valley.
If we're doing a major city (NYC, LA, Miami, Chicago, DC, London, Dublin etc), we're doing straight shots, no connections unless the price difference is so ridiculous and the layover is reasonable. Usually it's just easier to pay more for convenience.
Hawaii - that shyt is far as fukk. I don't mind flying out of Dallas and stopping in LA or SF first. You almost need the break.