Coronavirus Thread: Worldwide Pandemic

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Bloomberg Politics
The change should speed testing and allow state and local labs to start using hundreds of kits that were sent out earlier this month.

U.S. health officials will let state and local health labs modify a test for the coronavirus that has been plagued by weeks of delays, in an effort to better keep watch for cases that may be quietly arising in some parts of the country.

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U.S. to Expand Coronavirus Testing After Delays in Surveillance


what kind of half assed shyt is this?
 
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nyknick said:
:francis:
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Pope Francis falls ill day after supporting people with coronavirus


Pope Francis has missed a planned Mass with clergy in Rome due to an unspecified illness. The Vatican said the pontiff, 83, had a ‘slight indisposition’ and would proceed with the rest of his planned work today but ‘preferred to stay near Santa Marta’, the Vatican hotel where he lives. There was no word from the Vatican about the nature of his illness, but the pope was seen coughing and blowing his nose during the Ash Wednesday Mass. Yesterday, he told well-wishers: ‘I wish, again, to express my closeness to those who are ill with coronavirus and to health-care workers who are caring for them.’

It comes amid an outbreak of the strain of coronavirus – also known as Covid-19 – in Italy that has infected more than 400 people, almost all of them in the north. Rome had three cases, but all three have recovered. Francis had been scheduled to go to the St John Lateran basilica to meet with Rome clergy and celebrate a penitential Mass at the start of Lent. The Argentine pope has generally enjoyed good health. He lost part of one lung as a young man because of a respiratory illness, and suffers from sciatica, which makes walking difficult.


Francis has had a busy schedule lately, including his public general audience on Wednesday and the Ash Wednesday service later in the day in a Roman basilica. Some Lent Ash Wednesday services were cancelled or limited in areas of northern Italy hit by the spread of coronavirus. Twelve people have died of the disease in Italy, in the worst contagion from the coronavirus so far recorded in Europe.
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Pope Francis falls ill day after supporting people with coronavirus | Metro News

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Coronavirus far more likely than Sars to bond to human cells due to HIV-like mutation, scientists say
  • Research by team from Nankai University shows new virus has mutated gene similar to those found in HIV and Ebola
  • Finding may help scientists understand how the infection spreads and where it came from

The new coronavirus

has an HIV-like mutation that means its ability to bind with human cells could be up to 1,000 times as strong as the Sars virus, according to new research by scientists in China and Europe.


The discovery could help to explain not only how the infection has spread but also where it came from and how best to fight it.

Scientists showed that Sars (severe acute respiratory syndrome) entered the human body by binding with a receptor protein called ACE2 on a cell membrane. And some early studies suggested that the new coronavirus, which shares about 80 per cent of the genetic structure of Sars, might follow a similar path.

But the ACE2 protein does not exist in large quantities in healthy people, and this partly helped to limit the scale of the Sars outbreak of 2002-03, in which infected about 8,000 people around the world.

Other highly contagious viruses, including HIV and Ebola, target an enzyme called furin, which works as a protein activator in the human body. Many proteins are inactive or dormant when they are produced and have to be “cut” at specific points to activate their various functions.

When looking at the genome sequence of the new coronavirus, Professor Ruan Jishou and his team at Nankai University in Tianjin found a section of mutated genes that did not exist in Sars, but were similar to those found in HIV and Ebola.

“This finding suggests that 2019-nCoV [the new coronavirus] may be significantly different from the Sars coronavirus in the infection pathway,” the scientists said in a paper published this month on Chinaxiv.org, a platform used by the Chinese Academy of Sciences to release scientific research papers before they have been peer-reviewed.

“This virus may use the packing mechanisms of other viruses such as HIV.”

According to the study, the mutation can generate a structure known as a cleavage site in the new coronavirus’ spike protein.

The virus uses the outreaching spike protein to hook on to the host cell, but normally this protein is inactive. The cleavage site structure’s job is to trick the human furin protein, so it will cut and activate the spike protein and cause a “direct fusion” of the viral and cellular membranes.

Compared to the Sars’ way of entry, this binding method is “100 to 1,000 times” as efficient, according to the study.

Just two weeks after its release, the paper is already the most viewed ever on Chinarxiv.

In a follow-up study, a research team led by Professor Li Hua from Huazhong University of Science and Technology in Wuhan, Hubei province, confirmed Ruan’s findings.

The mutation could not be found in Sars, Mers or Bat-CoVRaTG13, a bat coronavirus that was considered the original source of the new coronavirus with 96 per cent similarity in genes, it said.

This could be “the reason why SARS-CoV-2 is more infectious than other coronaviruses”, Li wrote in a paper released on Chinarxiv on Sunday.

Meanwhile, a study by French scientist Etienne Decroly at Aix-Marseille University, which was published in the scientific journal Antiviral Research on February 10, also found a “furin-like cleavage site” that is absent in similar coronaviruses.

A researcher with the Beijing Institute of Microbiology, Chinese Academy of Sciences in Beijing, said the studies were all based on genetic sequencing.

“Whether [the virus] behaves as predicted will need other evidence including experiments,” said the researcher who asked not to be named.

“The answer will tell how the virus makes us ill,” he said.

Scientists’ understanding of the new coronavirus has changed dramatically over the past few months.

At first the virus was not considered a major threat, with the Chinese Centres for Disease Control and Prevention saying there was no evidence off human-to-human transmission.

But that assumption was soon invalidated, and as of Wednesday, there had been more than 81,000 confirmed infections around the world.

Chinese researchers said drugs targeting the furin enzyme could have the potential to hinder the virus’ replication in the human body. These include “a series of HIV-1 therapeutic drugs such as Indinavir, Tenofovir Alafenamide, Tenofovir Disoproxil and Dolutegravir and hepatitis C therapeutic drugs including Boceprevir and Telaprevir”, according to Li’s study.

This suggestion is in line with reports by some Chinese doctors who self-administered
HIV drugs
after testing positive for the new coronavirus, but there is as yet no clinical evidence to support the theory.
There is also hope that the link to the furin enzyme could shed light on the virus’ evolutionary history before it made the jump to humans.

The mutation, which Ruan’s team described as an “unexpected insertion”, could come from many possible sources such as a coronavirus found in rats or even a species of avian flu.
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Coronavirus more likely than Sars to bond to human cells, scientists say
 
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