I know some of these are not considered great shows but...
The Crowe family being a threat on Justified. Michael Rappaport was horribly miscasted as a Floridian gangster and did a twangy accent and his character was awful and a non threat. Raylan started to annoy me just for taking him serious.
Jax son being kidnapped on Sons Of Anarchy and them going to Ireland the whole season. Opie's death, he was one of the few likeable characters and he was given shyt after shyt and the audience wanted him to win so bad and they just brutally killed him. Juice becoming a turncoat because he's half black, later becoming Marilyn Manson's prison bytch. Lee Toric's whole existence on the show.
True Blood taking the vampire civil rights from a tongue and cheek part of the show to taking it serious and having a vampire lynched and dragged by his neck from a pick up truck. It was shytty because it invoked a real life racist murder of a black man and the vampires on the show have been shown to be murderous and prey on people, they're not completely sympathetic. Shapeshifters can only turn into humans if they killed another person, female shapeshifter posses this ability because her mom died giving birth to her implying she killed her mom. Jason being raped by female Werepanthers who want to breed with him and him viewing it as deserved for him being a womanizer. Tara a main character being killed off before the opening and using her death to absolve the guilt of her shytty mother. Terry ordering a hit on himself. The Obamas Vampire killing group. Having to kill off Alcide so Sookie wouldn't have to leave him for Bill. Bill dying so Sookie could move on and make a family with a human, again someone had to die so this bytch wouldn't have to make big girl decisions.