It's Spider-Man by far. He's the most relatable, the most honest, the most determined, has the best rogues, has the best relationships AND he's the one hero the other characters look up to, and aspire to be like.
Hell, he's the only character that maintains trying to balance a work/life/superheroing balance. Of course ish is gonna go awry, everytime, but he remains determined to do so, and will sacrifice his own happiness every time. By comparison, Doc Ock thrived as Spider-Man because he didn't give AF any of the little things.