I know the Wayans fell off with stuff like White Chicks, but they're still responsible for 3 of the greatest spoof movies of all time - Sucka, Menace and SM1. Scary Movie 2 was a rush release, which is why it wasn't as good. As a result they gave it to Zucker, SM3 is not bad as the genre goes. Don't remember 4 or 5 at all.
I just remembered Dance Flick, which was about 5 years too late to be popular at the time but was actually funny.
Theres also the Naked Gun remake coming soon. I have realistic expectations. The first time I watched Naked Gun and Scary Movie I was a teenager and was laughing the whole way through. I don't expect that, but if I get a couple of good laughs out of a silly comedy movie these days, thats enough.