Some might act like this doesn't mean anything but it does. With this conviction, the odds of him winning are slimmer now than before.
The GOP/Republicans definitely aren't excited about this because now they have a defacto candidate who in some ways already threw away the race. Which at this point, it'll have to be a miracle of some sorts for Trump to win with these conviction charges looming over him.
They have no choice but to run him at this stage of the campaign, it's too late for them to ride with another candidate. Honestly, this is the last go-around for Trump's chances of reelection, if he loses in November, conservatives won't back him in 2028.