I think people (understandably) confuse the 2 style changes from P after Murda Muzik/HNIC recording sessions. There was a definite fall-off from HNIC to Infamy. P has his sickle cell flare up and he also was not taking care of himself, and he was drinking too much, eating bad, etc. When he sounds lethargic and tired on Infamy, it's because he was doing pretty bad there. The verse on the 112 is the perfect example. It sounds like he's struggling to stay awake.
Now, there was a legit stylistic change once he got healthy, where he didn't go back to the Mura/HNIC flow, but he also wasn't lethargic and tired. This is what some Mobb heads call the
thugged-out spoken-word flow that he would largely maintain for the rest of his life. This had mixed results. Sometimes it was super dope, and other times not as much.
On Albert Einstein and Hegelian Dialectic (his final 2 solo projects) he actually brought back some elements of his earlier Hell on Earth and HNIC styles. He brought back the thing where he'd start the next bar off the last phrase of the bar he just ended on. That's all over Albert Einstein and Hell on Earth. His flow never returned to Hell on Earth form, but he absolutely made a choice to rap how he did in the 2nd half of his career.
TL;DR: I've asked as many people as possible (friends, other fans, and people that knew P) WHY he made the stylistic change, and I've never gotten a 100% clear answer. He could still go, though. His voice did stay deeper, and I don't know why that is. Peep his verse on this. It's not like Apostle's Warning or Still Shining, but he goes for a long time and it's really dope. It's his most underrated verse after Murda/HNIC. Video is time-coded to start on time. Also, last cool trivia fact @old boy . P had the flu when he recorded Keep It Thoro and that's why his voice sounds raspy and different on there. When asked if he wanted to re-record it, he liked the sound and kept it how it was.