basically, you do everything like normal, except you dont set off any blights until you have 16 out there...the blights dont go away in between rounds...the only way they go away is if they are eaten by the knights/vessel or set off.....that's why on hard, you gonna have to make sure to kill the knights and vessel every time....
the only parts i can see causing trouble:
- going into the bubble and fighting the echo 3 times...cause of the glitches it does sometimes....
- accidentally setting off a blight...
- getting over run by the extra adds after you kill the orges....
...those are the only things i can see causing issues, but all are easily manageable....cant wait to complete this and finally get that ship.....