Miguel cotto, an orthodox fighter with a very neat and traditional stance, to me he is a defensive genius, to the point that he is almost impenetrable on the inside, plus he has power and speed.
On the other hand we have an Orthodox Maywhether, who although has a very unconventional and vulnerable peek-a-boo style, possess the explosive speed and reflexes necessary to make it work for him perfctly.
Migull is a very proficient inside fighter, so his power and tight defense will aid him extremely well there, but on the outside he stands a small chance against Money. Don't get me wrong, he is ok on the outside, but lacks the speed necessary to truly dominate the likes of Mayweather.
Now Floyd Mayweather is simply an all rounder, he poses the speed, reflexes and power (but not as much power as miguell) to do well both inside or out, and his ring generalship is one of a kind.
The latter is where i believe Floyd has the advantage. As one poster already noted, Miguell will have to chase Maywether because i'm sure Maywether, due to the advise of his coach, will stick to fighting on the outside especially during the earlier rounds, therefore Miguel will have no choice but to chase him, which will ultimately lead to Miguel becoming excessively tired and vulnerable during the later rounds, making for an easy TKO decision for Floyd (if floyd boxes smartly).
That's my prediction; Miguel getting TKO'd due to strikes in the later rounds.
Either way this should be a very interesting fight because miguell and floyd are the complete opposite in terms of style. All scholars of pugilism will watch this one with anticipation.