Assuming all the rules are being enforced. (traveling, double dribble, goaltending and offensive and defensive fouls), im going with the small ball. Don Nelson of the Marvel Universe.
Starting 5:
Spidey: Can play both offense and defense. Agility and anticipation. Plus he on that GP level trash talk.
Reed Richards: Can play both offense and defense. Basketball IQ genius. Got that length.
Cap: Strength, speed, and agility. Also a handful on both offense and defense. Fast learner. Leader. Can calculate trajectory and ricochet angles for passing and shooting.
Bullseye: Offensive weapon. Pure scorer and passer.
Nightcrawler: Teleportation. Agility, speed. Offense and defense.
6th man:
Quicksilver: Speed. Good pair with nightcrawler, Spidey and bullseye for them fast breaks.
Coaching staff:
Professor X: Knows what both teams are thinking at all times. Link to Deathstroke to create constantly evolving game plans.
Deathstroke...Master tactitian... Game plans.