If you can find something cheap in Hell's Kitchen, you'll be aight. Just a few blocks from Times Square and in the middle of everything.
Don't do 40/40...hit Strata which is around the corner instead and the cover isn't odee. You can't go wrong with West 4th street for bytches and bars. 1st & 1st (near Houston Street) got some good small spots, hookah bars and other clubs (reggae spot somewhere around there...just ask around).
There's more than enough to keep you busy downtown. If you're into Jamaican chicks, hit up Mingles on Boston Road in the Bronx
Strip clubs in the BX are popping...in the daytime. Without a whip, it's too long a walk from the train station to the spots in Hunts point. Best be would be Sin City on E. 138th street. Perfections in Queens though...
Other than that, don't come Uptown. Ain't shyt here for a nikka that don't know nobody.