Not with Hip Hop. Pac disrespected Faith Evans on "Hit Em Up". And even if Biggie and Faith were on the outs, she was still mother to his son. Biggie's response was "if Fay had twins she'd probably have 2Pac's, get it: two Pacs". Jay Z brought up Nas's baby mother. Nas's rebuttal focused on Jay and while people say he made it personal, Jay made it personal first by bringing Carmen into it. Still, Nas's rebuttal focused on Jay. He could've talked about what Jay did to his own brother (legit since Jay made a song about it). Gucci and Shawty Lo mentioned Tiny in disses to T.I. Kim Kardashian was a punchline.
Like I said, Kendrick had already won it with the breakdown of Drake's family without ever hitting him with the pedophile accusations.