Movies have been adjusting/changing things that were based on other mediums (comic books, reg. books, games, etc.) since the get go. They're adaptions and that's part of the point, that they're not supposed to be 1:1 translations. Also, considering that the era that a lot of these books were made, which either isn't considering much other demographics out there (both from the consumers of said content and real world demographics in general) and/or are just antiquated ways of thinking and living since those times, it's only right that things that aren't that integral at least, would have drastic changes to take care of accommodations of the world of today.
You can make a point with race change of a character, for someone like Black Panther, would be a sin, since where his place of origin and entire mythos is too based and inclusive on his race for it to be changed. For someone where the race is more insensitive or stereotypically insulting, then the change makes more sense (like changing the Ancient One from some tibetian monk in Dr. Strange). In cases when race wasn't really integral or anything to begin with (such as Nick Fury being black in the MCU or Mary Jane being mixed), then it's really irrelevant if it was changed. When it involves someone in a case where those are not only not major factors, but is also even for something far more LITERALLY alien based, gender change in the case here doesn't really fukking matter.