How a dirty litter box could slow you down as you age
Some people infected with the common, cat-borne parasite Toxoplasma gondii are more likely to be frail as they get older, new research shows.
checkmateBy Lisa Marshall • Published: Nov. 6, 2023
A common, cat-borne parasite already associated with risk-taking behavior and mental illness in humans may also contribute to exhaustion, loss of muscle mass, and other signs of “frailty” in older adults, suggests a study published Nov. 6 in the Journal of Gerontology: Medical Science.
The research, by an international team of scientists including University of Colorado Boulder, University of Maryland School of Medicine and the University of A Coruña in Spain, is the latest to explore how the tiny, single-celled organism Toxoplasma gondii (T. gondii) could have big impacts on human health.
“We often think of T. gondii infection as relatively asymptomatic, but this study highlights that for some people it may have significant health consequences later on,” said co-author Christopher Lowry, a professor in the Department of Integrative Physiology at CU Boulder.
Approximately 11% to 15% of people in the U.S. have been infected with T. gondii at some point and rates tend to be far higher in older individuals. In some countries, more than 65% have been infected. Once infected, people can unknowingly harbor the parasite for life.
For the study, the team examined the blood of 601 Spanish and Portuguese adults over age 65, along with measures of a common geriatric syndrome known as “frailty” – which includes unintentional weight loss, tiredeness, loss of cognitive sharpness and other indications of declining health.
A whopping 67% of study subjects were “seropositive” showing markers in their blood of a latent infection.
The researchers did not, as they originally hypothesized, find an association between any infection to T. gondii and frailty. But they did find that, among those infected, those with higher “serointensity” or a higher concentration of antibodies to the parasite, were significantly more likely to be frail.
Higher serointensity could reflect a more virulent or widespread infection, multiple infections or recent reactivation of a latent infection, the authors said.
“This paper is important because it provides, for the first time, evidence of the existence of a link between frailty in older adults and intensity of the response to T. gondii infection,” said co-author Blanca Laffon, a professor of psychobiology at the Interdisciplinary Centre of Chemistry and Biology at University of A Coruña.
