George Jefferson = Sherman Hemsley (RIP)
Clair Huxtable = Phylicia Rashad
Barney Stinson = Neil Patrick Harris
Chandler Bing = Matthew Perry (RIP)
Steve Urkel = Jaleel White
New York = Tiffany Pollard
Uncle Phil = James Avery (RIP)
Susie Carmichael = Cree Summer
Omar Little = Michael K. Williams (RIP)
Carlton Banks = Alfonso Ribeiro
Ashley Banks = Tatyana Ali
Hilary Banks = Karyn Parsons
Myra = Michelle Thomas (RIP)
Blade = Wesley Snipes
Lucy Ricardo = Lucille Roberts (RIP)
Spock = Leonard Nimoy
Peter Griffin = Seth McFarlane
Buffy the Vampire Slayer = Sarah Michelle Gellar
40 Year Old Virgin = Steve Carrell
Nessa = Camille Winbush