One could say Macron is not a centrist and in that case, the right was already in control. If your question is about Le Pen then no I don't think she has a real chance this year.
IMO, the real danger will be in 5 years as Macron will not be eligible and Melenchon will be 76 (I thought he was already too old for this election). Then, Le Pen will be the candidate with the most brand recognition and political experience and I do think she will be the favorite
Isn’t Edouard Philippe very popular and basically waiting in the wings for the next election?
I expect him to replace Macron as the dominant center-right figure