I'd say yeah, but it really all depends on your perspective. If you enjoy "historic" cities and enjoy touring the different sights and sounds of the city, there's a good bit to see and a couple of companies that offer tours throughout the day.
On the food tip, there are some banging restaurants, so I got to try out two spots that I had heard about, and they more than met expectations. If you do decide to go, check out Alligator Soul and the Olde Pink House.
As far as partying, I just stuck to River st. It's pretty much a long as road with a bunch of restaurants, shops, and bars/clubs. There are riverboat cruise parties you can go on, and during the day there are different attractions going on. Plus you can drink openly on the street, so hopping from spot to spot isn't an issue.
Just my $.02.