I would say yes unless jeffrey and forte go crazy but it really depends on your league settings to be honest.
like do you get any points per rushing attempt for RB's, what yard threshold do you receive a bonus for reaching for RB's and WR's (100/150/200 yards) and do you get a bonus for 40+ yard TD's? in one of my leagues, I could easily lose a 52 point lead if I were you and in another I would have no way of losing with that kind of lead.