50 was on his sh*t around this time, he was in all out beef mode and he was on top of his game commercial wise etc. That was his absolute peak around this time and you can tell in the interview he was on top at the moment. These were good times in hip hop and it made for some great diss tracks all around, definitely legendary times as said above.
Even if you hated 50 you had to respect him, he never backed down nor bit his tongue to keep it civil. BTW you can tell the difference between this time and now how much he has grown as a person, he was a wild dude back in these days and settled down a lot later on sides the jokes on twitter etc. He squashed a lot of those beefs and had pics with most of those artists (Did shows with Nas too etc.).