Breakthrough treatment flips cancer cells back into normal cells

[bnew]

Breakthrough treatment flips cancer cells back into normal cells

Working with a line of colon cancer cells, Korean researchers figured out a way to throw a few genetic switches to cause the cells to revert back to a healthy state. The technique could have major implications in the way we approach cancer treatment.

newatlas.com

Breakthrough treatment flips cancer cells back into normal cells​

By Michael Franco

December 26, 2024

This generative image shows the concept the researchers proved of turning a cancerous cell back into a healthy cell

Working with a line of colon cancer cells, Korean researchers figured out a way to throw a few genetic switches to cause the cells to revert back to a healthy state. The technique could have major implications in the way we approach cancer treatment.

Most current cancer research and treatment involves finding ways to kill the rogue cells in our body to bring the disease under control. And there have been impressive strides made in this realm of investigation.

In traditional treatments though, most of the time, side effects arise because the body winds up losing cellular material and often, healthy cells and tissue die along with the damaged cancer cells. The collateral damage has typically been deemed worth it though, because when a treatment works, the cancer is destroyed and the patient lives.

Now though, researchers at the Korea Advanced Institute of Science and Technology (KAIST) have developed a different approach to combating the cells that cause cancer.

By using a digital model of the gene network of normal cell development, they found several molecules known as "master regulators" that are involved in the differentiation process of the cells lining the intestinal walls. These regulators are known as MYB, HDAC2, and FOXA2 and when they were suppressed in colon cancer cells, the cells switched back to a normal-like state, removing the cancer threat without destroying any cellular material.

The tests were carried out digitally, through molecular experiments, and in mice.

"The fact that cancer cells can be converted back to normal cells is an astonishing phenomenon," said KAIS professor Kwang-Hyun Cho, who led the research. "This study proves that such reversion can be systematically induced."

In addition to learning how to work with cancerous colon cells, the researchers also used their digital modeling program to discover four master regulators in the hippocampus region of mouse brains. Two of them were responsible for overexpression in the cellular differentiation process, while one was responsible for inhibition. The finding could be used to study and potentially reverse the spread of brain cancer, while the digital modeling tool could become a way to fight other cancers throughout the body.

"This research introduces the novel concept of reversible cancer therapy by reverting cancer cells to normal cells," concluded Cho. "It also develops foundational technology for identifying targets for cancer reversion through the systematic analysis of normal cell differentiation trajectories."

The research has been published in the journal Advanced Science.

Source: KAIST

 

[Rice N Beans]

I like the idea of this, but I think the application of this will be in a modified "predator" system to reconvert cancerous cells back or to be able to destroy them.

 

[Shysty]

Sounds like they succeeded

KAIST (President Kwang-Hyung Lee) announced on the 5th of February that Professor Kwang-Hyun Cho's research team of the Department of Bio and Brain Engineering has succeeded in developing a fundamental technology to capture the critical transition phenomenon at the moment when normal cells change into cancer cells and analyze it to discover a molecular switch that can revert cancer cells back into normal cells.

KAIST team discovers molecular switch to reverse cancer cells

Professor Kwang-Hyun Cho's research team has recently been highlighted for their work on developing an original technology for cancer reversal treatment that does not kill cancer cells but only changes their characteristics to reverse them to a state similar to normal cells.

www.news-medical.net

 

[PoorAndDangerous]

Sounds promising, still has to go through trials etc. I think there’s going to be a rapid medical advancement with A.I. continuing to progress

 

[Laidbackman]

Breakthrough treatment flips cancer cells back into normal cells

Working with a line of colon cancer cells, Korean researchers figured out a way to throw a few genetic switches to cause the cells to revert back to a healthy state. The technique could have major implications in the way we approach cancer treatment.

newatlas.com

​

Breakthrough treatment flips cancer cells back into normal cells​

By Michael Franco

December 26, 2024

This generative image shows the concept the researchers proved of turning a cancerous cell back into a healthy cell

Working with a line of colon cancer cells, Korean researchers figured out a way to throw a few genetic switches to cause the cells to revert back to a healthy state. The technique could have major implications in the way we approach cancer treatment.

Most current cancer research and treatment involves finding ways to kill the rogue cells in our body to bring the disease under control. And there have been impressive strides made in this realm of investigation.

In traditional treatments though, most of the time, side effects arise because the body winds up losing cellular material and often, healthy cells and tissue die along with the damaged cancer cells. The collateral damage has typically been deemed worth it though, because when a treatment works, the cancer is destroyed and the patient lives.

Now though, researchers at the Korea Advanced Institute of Science and Technology (KAIST) have developed a different approach to combating the cells that cause cancer.

By using a digital model of the gene network of normal cell development, they found several molecules known as "master regulators" that are involved in the differentiation process of the cells lining the intestinal walls. These regulators are known as MYB, HDAC2, and FOXA2 and when they were suppressed in colon cancer cells, the cells switched back to a normal-like state, removing the cancer threat without destroying any cellular material.

The tests were carried out digitally, through molecular experiments, and in mice.

"The fact that cancer cells can be converted back to normal cells is an astonishing phenomenon," said KAIS professor Kwang-Hyun Cho, who led the research. "This study proves that such reversion can be systematically induced."

In addition to learning how to work with cancerous colon cells, the researchers also used their digital modeling program to discover four master regulators in the hippocampus region of mouse brains. Two of them were responsible for overexpression in the cellular differentiation process, while one was responsible for inhibition. The finding could be used to study and potentially reverse the spread of brain cancer, while the digital modeling tool could become a way to fight other cancers throughout the body.

"This research introduces the novel concept of reversible cancer therapy by reverting cancer cells to normal cells," concluded Cho. "It also develops foundational technology for identifying targets for cancer reversion through the systematic analysis of normal cell differentiation trajectories."

The research has been published in the journal Advanced Science.

Source: KAIST

How can anybody from the US get the treatment?

Update: There's still further research, and clinical trials needed, before determining the safety of humans with this treatment.