Has Anyone Tried the Smart Drug Vasopressin

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Streamline your Thoughts with Vasopressin Nasal Spray

The ability to form and retain short and long-term memories, recall facts and articulate thoughts quickly can be honed with the smart drug vasopressin.
Acting on the hypothalamus – the part of our brain that’s responsible for ‘imprinting’ information – vasopressin nasal spray gives us the necessary power to keep up with the mental demands of life. Whether we need to remember facts and figures when studying or at work, or names, faces and events when socialising, the action of this vasopressin supplement is to provide more of the useful peptide hormone that’s involved in forming and retaining memories.
A timely spray of vasopressin can also charge our attention span, providing a grip on important details brought up in long conversations or when reading for extended amounts of time. This means we can stay focussed and ignore distractions – leaving lasting memories that can be recalled precisely when required.

Topping up a natural ‘smart’ chemical

Vasopressin is produced naturally by our pituitary gland – a pea-sized structure at the base of the brain. It’s known to help control the water balance in the body, by acting as an anti-diuretic hormone (or ADH), triggering a reaction in the body that conserves water and inhibits urine production. This is the reason why it’s sometimes prescribed to children who have a tendency to wet the bed or by those with a prostate condition – minimising the need to urinate at night. What’s also been discovered is that supplemental vasopressin has an ability to enhance mental clarity – especially where memory formation is concerned.
As vasopressin is organically released into the brain from the base of the pituitary gland, a direct effect is felt by another part of the brain called the hippocampus. This is the place in the brain where new information is turned into memory and transferred to short-term and long-term mental ‘filing’ systems.
Supplemental vasopressin has the capacity to enhance cognitive speed and power at whatever stage in life. It’s known that naturally our vasopressin levels decline with age, so there’s a distinct benefit to keeping the levels up and our minds sharp now, which will pay dividends in increased mental clarity later.

How vasopressin works

Working to regulate how much fluid and therefore salts we retain, when vasopressin is released, the kidneys react to conserve water, and concentrate the urine. This is a process that usually occurs when we’re dehydrated, so we can optimise the levels of existing fluid in our body.
As well as the signalling mechanism vasopressin exerts on the kidneys and our fluid retention levels; it's also known to act as a vasoconstrictor. This means that the muscular walls of our blood vessel's contract and are made narrower, just as when we feel cold and blood is channelled to vital places in the body.
Vasopressin is also a nootropic supplement – it belongs to a branch of medicines and supplements that help cognitive ability. This is what’s caught the attention of doctors and those wishing to attain better memory and quicker recall. Vasopressin nasal spray gets to work quickly – by being easily absorbed by the membrane in the nostril. A spray into each nostril 15 minutes before an important meeting or at any time when enhanced recall is required will see marked effects in formation of memories and accurate recollection when needed at a later date.

Using Vasopressin

As well as the enhanced cognitive ability, it’s important to use vasopressin in the right quantities, so check the label for frequency and for potential contraindications with other medicines or conditions. Generally, side effects like headaches or nausea are seldom experienced. However, as a general rule, it’s advised not to take the supplement before heavy exercise, swimming, or when intending to drink lots of fluids, i.e. alcohol. As it affects the arteries and is a vasoconstrictor, it should be avoided if you suffer from cardiovascular problems. Vasopressin nasal spray is derived from porcine origins, so there’s a closer synthesis with own hormone production. As with any medicine, it’s necessary to talk to your doctor before beginning any course of treatment.
Vasopressin is sometimes prescribed for those suffering from amnesia, Alzheimer’s disease, or depression, and studies show that in age-related examples of memory loss, it improves memory and mood. Another benefit of vasopressin that has recently been discovered is that’s useful for promoting ‘slow wave sleep’. This is when our resting cycle works at its best, regenerating cells and repairing tissue. Vasopressin has also been known to increase production of HGH, the human growth hormone – vital for restorative cell processes.

Get up to speed with vasopressin nasal spray

Using the supplement in a nasal spray form means it’s easy to get the benefits handily and quickly. Its memory and imprinting power is highly useful for keeping one step ahead in today’s busy world. By virtue of where it works in the brain, we’re able to improve the efficiency at which our mind can form and hold onto memories now and in the future.
Note: IAS provides both the synthetic versions (desmopressin) as well as the porcine sourced vasopressin nasal sprays.

Vasopressin - Wikipedia, the free encyclopedia
Vasopressin an antidiuretic hormone (ADH) used for memory and recall
[Arg8]-Vasopressin solution Grade VI (synthetic), ~100*I.U./mL in 0.9% NaCl | Sigma-Aldrich :shaq:
 

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VASOPRESSIN - Definitely the most euphoric of the memory-enhancing intelligence-increase drugs. Vasopressin is marketed as Diapid, a prescription drug made by our old friends Sandoz. It can also be ordered as Vasopressin through chemical supply houses by those who know the ropes. I had five squirts of Vasopressin out of a nasal inhaler. I was surprised by how strong the effects were. I had that charged-up hyperconfident rush that one experiences with cocaine, but combined with much clearer ideation and without the numbing and discomfort or the strange and disquieting hard edges which often accompany even the more euphoric coke highs. It didn't last very long, about two hours, most of which unfortunately spent riding the BART and walking. By the time I got home, the experience had pretty well dissipated. I did not have an opportunity to experience Vasopressin as a work/writing drug. It was clear, however, simply from reading (I was reading "Gravity's Rainbow" at the time and I consider that a fairly challenging test of comprehension) on the BART ride home, that Vasopressin is an excellent tool for rapid learning and comprehension of complex systems of thought.
 

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Interesting

VASOPRESSIN

"The most immediate result I get from using vasopressin is increased clarity and alertness. I can be logical without the usual speediness associated with caffeine use. After five minutes I've noticed that I'm busily accomplishing tasks that I'd been putting off for a week. The duration is about two hours for the energetic feelings. Overall, I feel my short-term memory recall improving over the past two weeks of using vasopressin. It seems that the longer I use it, the more I can rely on my mind to be a portable note pad."

"I have smoked pot on a more or less (usually more) daily basis for 20 years. When I read that vasopressin is inhibited by pot, I found a source for buying some. Now I notice that when I use vasopressin with marijuana I still get stoned, but I have little or none of the 'dummying down' effect of the pot. And what a surprise to find that vasopressin intensifies orgasms!"

Vasopressin, called "the memory hormone," is a natural brain peptide, stimulated by acetylcholine and released in the pituitary. It actually helps create, imprint, and store memories, and is essential to remembering. Apparently vasopressin is involved in picking out and chunking together related bits of information from the stream of consciousness, integrating these chunks into coherent structures, and then "imprinting" these images or concepts into long-term memory by transforming electrical impulses into complex proteins that contain memories and are stored away in the brain. The act of remembering the stored information is also mediated by vasopressin.

Over 20 years ago scientists discovered that vasopressin had extraordinary effects on the memory of laboratory animals-- preventing chemically and electrically induced amnesia, actually reversing amnesia, and dramatically boosting the memory and intelligence of normal animals. These findings spurred much research into the cognition-enhancement effect of vasopressin on humans. Among the key findings are that small doses of the hormone can have striking success in quickly reversing traumatic amnesia (amnesia caused by injuries such as car crashes), can reverse age-related memory loss and actually restore lost memories, and can produce sharp improvements in learning and memory using measures such as abstract and verbal memory, organizational capacities, recall, attention, concentration, focus, short-term memory, optical memory, and long-term memory. It also boosts performance in such areas as reaction speed, visual discrimination, and coordination.

Vasopressin pours out during moments of trauma or extreme arousal, which may explain why those times seem to be so deeply imprinted in our brains, and are remembered with such clarity. Vasopressin is also released by cocaine, LSD, amphetamines, Ritalin, and Pemoline (Cylert). Those who make frequent use of these drugs deplete their brain's vasopressin supply. The result is depression, and a decline in cognitive function. The frequent user's response to this depression is to take more of the drug, thus trying to wring more vasopressin out of their depleted brain: ultimately the well runs dry. Vasopressin, however, is not a drug but the actual brain hormone that has been depleted, so it can produce dramatic and virtually instantaneous improvements in mood and mental functioning.

Unlike stimulants, alcohol and marijuana do not deplete but actually suppress the release of vasopressin, which could account for the loss of memory many have noticed when drunk or stoned, or when trying to remember events that occurred while they were high. Vasopressin can reduce the harmful effects of these drugs and enhance alertness, reaction speed and concentration.

Anecdotal evidence suggests that vasopressin can produce a state of euphoria accompanied by self-confidence, energy, assertiveness, and a sensation of extreme mental clarity. Many believe it is ideal for situations in which lots of new information needs to be processed and remembered--such as studying for an exam, learning a language, ploughing through difficult or complex works. Some use it for more mundane purposes, such as when they have to drive late at night and want to remain alert.
 

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Desmopressins' effects rapidly improve short-term memory and enhance memory imprinting. Desmopressin is usually "approved" for the treatment of diabetes insipidus, (a condition of frequent urination and extreme thirst). This is because desmopressin is also involved in this body function. However in some countries, its uses have been for amnesia, and for patients suffering from mental difficulties caused by the abuse of narcotics.

As desmopressin is partly responsible for the "deposit" of memories in the hippocampus, (the region of the brain where memories are stored), it presents a unique aspect. When desmopressin is taken before an event, it enables the event to be recalled with more detail later. Whereas "normal" memory-drugs improve the capability to remember past events easier and faster, desmopressin helps us to remember future events better! This type of effect is referred to as memory imprinting.

So desmopressin is of particular benefit before lectures, business meetings and other such occasions. One conference attendee remarked to me, that he thought desmopressin was the ideal product for conferences; not only did he remember more of it, but it also helped him prevent trips to the rest-room!

The use of desmopressin 15 minutes before recall or concentration is required, (by inserting one or two sprays into each nostril- each spray contains 10mcg), can produce a marked affect, sometimes within seconds and the effect can then last for up-to several hours.
 

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Vasopressin- The Anti-aging, Cognitive Enhancing Neuropeptide

Vasopressinis a pituitary hormone that is best known for controlling water balance in the body. Its common name is anti-diuretic hormone (ADH), because of its property of conserving water in the body, and inhibiting urine production. Because of this property, many parents of children with bed-wetting problems find it useful, as do many men with prostate problems (BPH). Vasopressindoesn't effect the prostate, but it does reduce urine production, resulting in less sleep interruptions.

Vasopressinas a Smart Drug

However, vasopressin also acts as a neuropeptide in the hypothalamus, and is necessary for imprinting new information in our memories. Not surprisingly, vasopressin content in the brain declines with age. Consequently, Vasopressinhas been used to treat memory deficits due to aging, senile dementia, Alzheimer's disease, Korsakoff's Syndrome and amnesia. Vasopressinimproves attention, retention and recall (both short-term and long-term) and it is well known to enhance short-term memory in normal young adults, as well as in those with age-associated memory impairment (AAMI). In addition, it has been shown to improve both mood and memory in the elderly and those with Alzheimer's disease.
Vasopressinis very useful when learning large amounts of new information. It can increase the ability to memorize and recall, and is especially helpful when cramming for exams, trying to memorize a speech, or learning a script.
A recent study demonstrated an additional, previously undocumented benefit of Vasopressin-enhancement of slow wave sleep (Perras, et al, 1999). Subjects in this study used a dose of 40 IU/day, administered as a nasal spray (two sprays at bedtime). Over a period of three months, the researchers found the time spent in slow wave sleep (SWS) more than doubled. SWS is the most restful kind of sleep- and it is during SWS that growth hormone is released.
Perras and colleagues hypothesized that in addition to its direct effects as a neuropeptide, Vasopressincould act by other mechanisms as well, including acting as a corticosteroid receptor agonist (sensitizer).

Potential Anti-Aging Effects of Vasopressin

Drs. Sydney and Constance Friedman at the University of British Columbia studied the effects of posterior pituitary powder on the life spans of already-old rats (2 yrs). The scientists proposed that the alterations in water and electrolytes (principally, sodium and potassium) with age, resemble those of diabetes insipidus (a disease characterized by excessive urination caused by a lack of ADH). They further proposed that many other signs and symptoms of aging are similar to many features of diabetes insipidus (Findley, 1949). They had previously found that Vasopressin(ADH) restored a youthful pattern of fluid distribution in rats (Friedman, et al, 1960, 1963 ), and improved renal function in aging men (Ruol, et al, 1963).

The authors stated that "It is a truism that in age almost all functions that can be measured will show some decline [Ed.- For proof, see Dr. Dean's book, Biological Aging Measurement - Clinical Applications]. Since salt and water homeostasis is certainly central to life itself, [effective therapy] might well produce a measurable effect on life span."

To test their theory, the authors administered posterior pituitary powder, (as a source of vasopressin) to two year-old rats. The study was terminated after 180 days. Only 8 of the original 18 controls were still alive. In contrast, 22 of 36 treated rats survived (Fig. 1). The authors also reported better fur condition, increased muscular tone, absence of age-related pituitary and adrenal enlargement, and fewer skin lesions in the treated rats. The scientists concluded that "therapy directed at the neurohypophyseal-adrenal cortical integration can exert profound effects...in the aging organism." [Ed.- That was a pretty profound statement in 1964].

DesmopressinTM is synthetic vasopressin. It is indicated for diabetes insipidus, as well as nocturnal eneuresis (bed-wetting), but can be taken safely by most people. Those with hypertension, glaucoma or prostatic hypertrophy should use Desmopressinwith caution and only under the care of their physician. Vasopressinoccasionally produces the following side effects: nasal congestion, runny nose, itch or irritation of the nasal passages, abdominal cramps, headache and increased bowel movements. Vasopressinhas not been proven to be safe for use during pregnancy.
Vasopressincomes in three forms: lysine-vasopressin(Diapid, LVP, Lypressin, Postacton, Syntopressin): l-desamino-8-D-arginine (Adiuretin SD, DAV, Ritter, DDAVP, Desmopressin, Desmospray, Minirin, Minurin) and arginine-vasopressin(Argipressin, AVP, rinder-vasopressin). All forms have very similar or identical effects. The availability of Vasopressinvaries due to intermittent unexplained withdrawals and reintroductions into the marketplace by the pharmaceutical companies. It is available in the USA by prescription, although most physicians will probably not be familiar with the uses discussed here. It can be purchased over the counter in Mexico or by mail from overseas pharmacies. It is available as a nasal spray by prescription, or from an overseas pharmacy like IAS.

Because of Vasopressin's multiplicity of benefits, I believe it is a potentially valuable anti-aging, life extending agent. Even in those for whom it is relatively contraindicated (i.e., those with hypertension or glaucoma), I think long-term, low-dose use may ultimately be beneficial.

References:
1. de Wied, D, van Wimersma Greidanus, TB, Bohus, B, Urban, I, Gispen, WH. "Vasopressinand memory consolidation." Perspectives in Brain Research. New York: Elsevier Scientific Publishing, 1975.
2. Friedman, S.M., and Friedman, C.L. Prolonged treatment with posterior pituitary poweder in aged rats. Exp Gerontol, 1964, I: 37-48.
3. Gold, PW, Weingartner, H, Ballenger, JC, Goodwin, FK. "Effects of l-Desamo-8-Arginine Vasopressinon Behavior and Cognition in Primary Affective Disorders." The Lancet, November 10, 1979, pp 992-94.
4. Laczi, F, Valkusz, Z, Laszlo, FA, Wagner, A Jardanhazy, T, Szasz, A, Szilard, J, Telegdy G. "Effects of Lysine-Vasopressinand l-Deamino-8-Arginine Vasopressinon Memory on Healthy Individuals and Diabetes Insipidus Patients." Psychoneuroendocrinology, 1982, Vol. 7, No 2, p 185-92.
5. Legros, JJ, Gilot, P, Seron, X, Claesens, J, Adam, A, Moeglen, JM, Audibert, A, Berchier, P. "Influence of Vasopressinon Learning and Memory." The Lancet, January 7, 1978, p41-42.
6. Oliveros, JC, Jandali, MK, Timsit-Berthier, M, Remy, R, Benghezal, A, Audibert, A, Moeglen, JM. "Vasopressinin Amnesia." The Lancet, January 7, 1978 p43.
7. Pearson, D., Shaw, S.Life Extension, A Practical Approach. New York, Warner Books, 1982.
8. Pelton, R., Pelton, TC. Mind Food and Smart Pills. New York, Doubleday, 1989.
9. Perras, B., Pannenborg, H., Marshall, L., et al. Beneficial treatment of age-related sleep disturbances with prolonged intranasal vasopressin. J Clin Pshychopharmacology, 1999, 19: 1, 28-36.
10. Ruol, A., Menozzi, L, and Furlanello, F. J Geront Suppl 31, 1963.
Authors
DEAN MD, WARD
 

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Yada yada brehs, whats the side effects :comeon:

Side Effects
Most people using Desmopressin find it causes them no problems. Occasionally some people suffer from headache, stomachache, nausea, blocked or runny nose or nose bleeds. Allergic reactions to the preservative such as skin rash, itching or sore nose can occur rarely. If you experience one or more of these side effects or any other undesirable effects please tell a nurse or doctor.
Excessive fluid intake may lead to a build-up of water, which dilutes salt in the body. This is a serious condition and may lead to convulsions. If an unusually bad or prolonged headache, confusion, nausea, or vomiting occurs, immediately contact the doctor or the nearest hospital casualty department before taking another dose.
Storing the Medicine
Desmopressin may be stored at room temperature (up to 25 degrees Celsius). It must be protected from light. Do NOT use Desmopressin if it is past the expiry date on the packaging. If you are unsure about the storage, ask your pharmacist. It is best to return all old and unused medicines to your pharmacist for safe disposal. Please do NOT throw this leaflet away until the medicine is finished, as it may be needed again.
How to use Desmopressin Nasal Spray
Remove the protective cap
When first used prime the spray by pressing several times until a consistent, fine spray is seen.
With your head tilted slightly back, place the nozzle just inside the nostril.
Hold your breath (Do not sniff) and press the spray once.
Repeat this procedure using alternate nostrils until the prescribed dose is reached.
Replace the protective cap after use.
Store upright at room temperature.
If the spray is not used within 7-days of the previous date, re-prime by pressing the spray at least once before using.

The above information is the translation of the manufacturer's insert. It is provided under the supplying company's terms and conditions and should not replace the advice of your personal physician.

:ehh: :smugfavre:
 
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